Lifespan : Why We Age – and Why We Don’t Have To
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- Update Date：2025-09-06
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- Author：David A. Sinclair
- ISBN：0008380325
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Summary
It’s a seemingly undeniable truth that aging is inevitable。 But what if everything we’ve been taught to believe about aging is wrong？ What if we could choose our lifespan？
In this groundbreaking book， Dr。 David Sinclair， leading world authority on genetics and longevity， reveals a bold new theory for why we age。 As he writes: “Aging is a disease， and that disease is treatable。”
This book takes us to the frontlines of research many from Dr。 David Sinclair’s own lab at Harvard—that demonstrate how we can slow down， or even reverse， aging。 The key is activating newly discovered vitality genes， the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it。
In this groundbreaking book， Dr。 David Sinclair， leading world authority on genetics and longevity， reveals a bold new theory for why we age。 As he writes: “Aging is a disease， and that disease is treatable。”
This book takes us to the frontlines of research many from Dr。 David Sinclair’s own lab at Harvard—that demonstrate how we can slow down， or even reverse， aging。 The key is activating newly discovered vitality genes， the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it。
Reviews
Kes
，
I took a while to get into it， because something about the writing is just so incredibly smug。 The first chapter felt like an autobiography。The remaining chapters improved by going into the science of ageing， but there are a few threads here:1。 How the author's experiences influence his outlook on age （age is a disease）2。 How the author's philosophy underlies his science （age should be cured）3。 The science of ageing and the medicines that cure it （NMN and resveratrol） （including how he takes the I took a while to get into it， because something about the writing is just so incredibly smug。 The first chapter felt like an autobiography。The remaining chapters improved by going into the science of ageing， but there are a few threads here:1。 How the author's experiences influence his outlook on age （age is a disease）2。 How the author's philosophy underlies his science （age should be cured）3。 The science of ageing and the medicines that cure it （NMN and resveratrol） （including how he takes these pills to help himself）In short: there's less science then I expected。 It's a readable book - if you like the author。 You can choose to read his anecdotes as personal snippets to add a storytelling touch， or mere bloviating。 At times it leaned towards the latter for me。 I appreciated the illustrations though。This review also does a good job at describing the controversy surrounding the author: https://www。bostonmagazine。com/health。。。 。。。more
Christine Kenney
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So you've seen this dude guest on vlogs， learned he is actually ~15 years older than he looks， and wondered what he's doing-- skip to the bulleted list in the conclusion。 Think of chapters 4 & 5 as footnotes。The mixed analogies about gene expression in chapters 1-3 should have been a video。 The implications explored in chapters 6-9 will make for some great speculative fiction。 So you've seen this dude guest on vlogs， learned he is actually ~15 years older than he looks， and wondered what he's doing-- skip to the bulleted list in the conclusion。 Think of chapters 4 & 5 as footnotes。The mixed analogies about gene expression in chapters 1-3 should have been a video。 The implications explored in chapters 6-9 will make for some great speculative fiction。 。。。more
Cynthia Feldmann
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Amazing - life changing， attitude changing - although some of the early chapters focus heavily on biology and the science of human cells - the background is informative and a necessary prelude to establishing the current state of the understanding of cell aging！ I so recommend this book！
Bob
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Why this book: I had heard David Sinclair interviewed by Peter Attia and was impressed with the interview。 I have just read The Longevity Paradox， and wanted to see what Sinclair had to say that might fit with， or contradict what Gundry had said in his book （they are pretty much in synch。） Also， Sinclair and his views were among the original sources of my interest in the new longevity， about which I wrote in my essay a few years ago。Summary in 4 Sentences: This book makes 4 important claims: Fi Why this book: I had heard David Sinclair interviewed by Peter Attia and was impressed with the interview。 I have just read The Longevity Paradox， and wanted to see what Sinclair had to say that might fit with， or contradict what Gundry had said in his book （they are pretty much in synch。） Also， Sinclair and his views were among the original sources of my interest in the new longevity， about which I wrote in my essay a few years ago。Summary in 4 Sentences: This book makes 4 important claims: First that aging is a disease and the symptoms of aging as we now know it， are not pre-determined and can be delayed by decades or potentially indefinitely。 Second， that research is progressing rapidly to better understand the biological processes of aging， and scientists are finding ways to arrest these process。 Three， there are cultural and institutional impediments to progress in this field， given that our medical system is invested in treating diseases， rather than preventing them and promoting vitality and longer health span。 And Four， that it is inevitable that significantly increased life and health spans will be available to those who can afford the coming medicines and treatments， but that change will cause some significant social disruptions， and the world is not ready。 My Impressions: This is a wonderful book， exciting to read， even if I didn’t understand ALL the bio physiology。 He explains why and how he is certain that in the next few decades， life expectancy for those living in healthy societies will increase by 50% and more。 Don’t believe it？ He uses the analogy of how in less than a century， we went from the Wright brothers to putting a man on the moon。 Or from a pocket calculator and a walky-talky to a cell phone connected to the whole world and the knowledge of the ages。 Sinclair’s enthusiastic belief in this vision of significantly increased life and health span is infectious， but he doesn’t shy away from the challenges his prognosis presents。 Lifespan is written in three parts: Part 1 WHAT WE KNOW （THE PAST）。 In Part 1， he introduces us to some of the research that has led to the key bio-physiological bases for his predictions。 A key player in the Longevity drama is our sirtuins。 He describes how sirtuins ” order our bodies to ‘buckle down’ in times of stress， and protect us against the major diseases of aging: diabetes and heart disease， Alzheimer’s disease and osteoporosis， even cancer。 They mute the chronic overactive inflammation that drives diseases such as atherosclerosis， metabolic disorders， ulcerative colitis， arthritis and asthma。 They prevent cell death and boost mitochondria， the power packs of the cell。” p 24 Activating and energizing our sirtuins is one of the keys to increasing our longevity and health span。 Sirtuins are a key player throughout the book。Much of the rest of Part 1 is Sinclair making the case that aging is something that we have assumed is the way it has to be， but aging can be hacked and “cured。” He notes that while lifespans have increased， “health spans” have not – we have kept unhealthy， unhappy people alive for decades longer than in the past。 This is not acceptable。 He notes that many of the diseases that afflict the aged can be dramatically mitigated if not “cured，” by better understanding the microbiological processes by which we deteriorate。 He gives us numerous examples of research with mice and other mammals which have had amazing results， and that some of these insights are already moving into therapy for humans。 PART 2。 WHAT WE’RE LEARNING （THE PRESENT） This is a heavy chapter which outlines the many lines of research that are supporting his thesis that aging can be “cured” and he explains the steps that anyone can and should take to extend not just their lifespan， bur more importantly， their health span。 He discusses the research about why creating healthy stress to the body creates long term resilience -stresses such as fasting， exercise， High Intensity exercise， heat stress， cold stress – anything which stimulates the body at the cellular level to make itself stronger and more resilient to prepare for such future stresses。 Our bodies have to be nudged， or even shoved to adapt， to become stronger and more resilient。 He writes that “ A bit of adversity or cellular stress is good for our epigenome because it stimulates our longevity genes。” （p112）He notes how our biology is designed for us to live long enough to reproduce and raise our young。 After that our evolutionary/biological work is done。 Some of what has evolved to help us survive and thrive while we’re young and reproducing and raising children， is no longer useful and becomes counterproductive as we age。 Scientists are exploring how to identify and modify these biological mechanisms that have outlived their usefulness and can inhibit health and well-being once we’re beyond our reproducing and child rearing years。 For example， senescent cells are not normally a problem for young people。 But they apparently are an important part of the aging process for those of us who are older。 MEDICAL INNOVATION:Pharmacogenetics – the increasing realization that medication acts differently among people of different genotypes， including often having very differently effects on men and women。 “Eventually ， every drug will be included in a huge and ever expanding database of pharmacogenteic effects。 It won’t be long before prescribing a drug without first knowing a patient’s genome will seem medieval。” （p184） With a simple blood test， doctors will be able to scan for circulating cell-free DNA。。 and diagnose cancers that would be impossible to spot without the aid of computer algorithms…We’re going to get ahead of symptoms。 Way ahead。 We’re even going to get ahead of “feeling bad，’ Many diseases， after all， are genetically detectable long before they are symptomatic。” p186He writes that”Once you recognize that there are universal regulators of aging， in everything from yeast to roundworms to mice to humans… and once you realize that it’s all one disease， it all become clear: Aging is going to be remarkably easy to tackle。 p147-8PART 3。 WHERE WE’RE GOING （THE FUTURE） In this final part of his book， Sinclair gives warning – there are serious problems that accompany the opportunity to live decades， perhaps even centuries longer。 And he looks at social and political trends internationally that are related to， and will impact the movement toward increasing health and life span。He writes， “Most people， upon coming to the realization that longer human lives are imminent， also quickly recognize that such a transition cannot possibly occur without significant social， political， and economic change。 。。there can be no evolution without disruptions。” （p219）This section is a fascinating potpourri of issues that he is concerned with， that are related to his work in defining aging as a disease and improving life and health span。 。CONCLUSION: He writes that “Although I’m very optimistic about the prospects for prolonged vitality， I’m not that optimistic。 I don’t know any reputable scientist who is。 One hundred years is a reasonable expectation for most people alive today。 One hundred twenty is our known potential and one that many people could reach – again， in good health if technologies in development come to fruition。 If epigenetic reprogramming reaches its potential， or someone comes up with another way to convince cells to be young again， 150 might even be possible for someone living on this planet with us right now。 And ultimately there is no upward biological limit， no law that says we must die at a certain age… But these milestones will come one at a time， and slowly。 Death will remain a part of our lives for a very long time to come， even as the time of it is pushed out in the coming decades。” p 247-8This is an abbreviated version of the review I wrote。 If you’d like to read the entire review， go to:https://bobsbeenreading。wordpress。com。。。 。。。more
Gleniz
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3。5 🌟
Abhishek
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It offers an in depth knowledge of our DNA and why we age， and how evolution has built an ALMOST perfect organism but with DNA repetition comes slight errors， and these errors compound over a period to a gradual deterioration of human body， which is agingThe book is highly technical， with jargons which are often alien to people not from life sciences But if you are looking to read an exhaustive book on human DNA evolution， then its a good read， if not you might loose interest and get lost in the It offers an in depth knowledge of our DNA and why we age， and how evolution has built an ALMOST perfect organism but with DNA repetition comes slight errors， and these errors compound over a period to a gradual deterioration of human body， which is agingThe book is highly technical， with jargons which are often alien to people not from life sciences But if you are looking to read an exhaustive book on human DNA evolution， then its a good read， if not you might loose interest and get lost in the technical narrative。 。。。more
Rebecca
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I feel I may be a bit too harsh， however， so much of what "science" teaches has been clearly disproven and I'm so over it。 I tried to the book several times and I just couldn't "get into it。" The author does share lots of info that's really accessible in many other ways than this book， and many of those ways are much more enjoyable。 I feel I may be a bit too harsh， however， so much of what "science" teaches has been clearly disproven and I'm so over it。 I tried to the book several times and I just couldn't "get into it。" The author does share lots of info that's really accessible in many other ways than this book， and many of those ways are much more enjoyable。 。。。more
Jessica
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Lots to think about with this one！Biology of aging， Strategies for living longer and implications if we do。
Sara （BookshelfSOS）
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I really， really enjoyed this book。 The science was fascinating， but more than that the overall sense of optimism was so refreshing。 It put things in perspective and reminded me that the world is actually pretty amazing and human lives are improving through technology and innovation， no matter how much the news tries to scare you into thinking doomsday is nigh。 David Sinclair was a charming narrator （I listened to him read the audiobook） and I found myself really liking him as a person in additi I really， really enjoyed this book。 The science was fascinating， but more than that the overall sense of optimism was so refreshing。 It put things in perspective and reminded me that the world is actually pretty amazing and human lives are improving through technology and innovation， no matter how much the news tries to scare you into thinking doomsday is nigh。 David Sinclair was a charming narrator （I listened to him read the audiobook） and I found myself really liking him as a person in addition to being very impressed by his work。 。。。more
David Miller
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Really interesting progress in longevity that I think a lot of people aren't that aware of。 It is hard to take claims like this seriously because for decades the supplement industry has been selling cures and anti-aging bs， but it seems biology has finally caught up to being able to make genuinely effective drugs to reduce aging related disease。 Really interesting progress in longevity that I think a lot of people aren't that aware of。 It is hard to take claims like this seriously because for decades the supplement industry has been selling cures and anti-aging bs， but it seems biology has finally caught up to being able to make genuinely effective drugs to reduce aging related disease。 。。。more
Sukh Saigal
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Lifespan book is very good book who want young:-） 。。 very knowledgeable and little tough。 A lot of key ideas for life like Aging is a disease ， The information Theory of aging。 ， The longevity genes。， Activating the survival network， chemical and technological routes to longer life ， Implementation for our future。Many more knowledge Dr。 Sinclair is an award-winning in the field of aging。I recommend highly to everyone。
Yugvir
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Not only should everyone read this， they should also start imagining a world completely different from the one right now。 Even though Dr Sinclair is extremely optimistic about the human condition， he does discuss the risks and concerns regarding his research on aging and these are conversations that realistically don't seem far off in the future。 （Oh and it's not _as_ research heavy as I'd liked it to be but I'm not in that field of research so I think it caters well to a larger audience）Also I' Not only should everyone read this， they should also start imagining a world completely different from the one right now。 Even though Dr Sinclair is extremely optimistic about the human condition， he does discuss the risks and concerns regarding his research on aging and these are conversations that realistically don't seem far off in the future。 （Oh and it's not _as_ research heavy as I'd liked it to be but I'm not in that field of research so I think it caters well to a larger audience）Also I'm definitely going to make some lifestyle changes ！ 。。。more
Paul
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This review has been hidden because it contains spoilers。 To view it， click here。 it's a game changer。 read it！ it's a game changer。 read it！ 。。。more
Adam Bregman
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A science book seeking bestseller status with a revolutionary and future-thinking manifesto， Lifespan furnishes scientific data and humanist arguments to live up to its title thesis: Why We Age -- And Why We Don't Have To。 One of the more prominent scientists working on human longevity， David Sinclair considers ageing a disease and wants the rest of the world to catch up with him in this radical assertion。 There's no telling if Sinclair is correct about the age of humans reaching into the 100s s A science book seeking bestseller status with a revolutionary and future-thinking manifesto， Lifespan furnishes scientific data and humanist arguments to live up to its title thesis: Why We Age -- And Why We Don't Have To。 One of the more prominent scientists working on human longevity， David Sinclair considers ageing a disease and wants the rest of the world to catch up with him in this radical assertion。 There's no telling if Sinclair is correct about the age of humans reaching into the 100s sooner rather than later based on numerous experiments on mice and some anecdotal information， much of it focusing on Sinclair's father， who turned his life around after following the same course Sinclair takes using gene-boosting supplements and living healthily。 Sinclair is so optimistic and his ideas so utopian that it's difficult to share his vision。 Few scientists are as assured about the future。 He does discuss the many possible downsides of humans aging decades more， but he is more concerned with the upsides。 He mentions that it's possible that at first it will be just the very rich who can afford to extend their lifespans， but his perpetual optimism slaps away all negative repercussions in favor of continuous hopefulness。 Through the three sections of the book focusing on the past， present and future， the first including all of his complex genetic research， Sinclair returns to his thesis that human aging is a disease that must be cured by science。 Whatever happens in the future， it's difficult to imagine Sinclair's dreamworld of seniors starting new careers in their eighties and the world's troubles defeated by humans living longer while using less of the world's resources for the betterment of all。 That doesn't mean that many of Sinclair's predictions won't come true。 He does know as much about the subject of human longevity as anyone。 But while the future doesn't have to be an environmental disaster， though that does seem more likely than some of Sinclair's aspirations， it's more likely to play out， as things do， having a lot of bad with the good， somewhere in the middle， neither Valhalla， nor Armageddon， with people living longer， some of them healthily， while others are miserable。 。。。more
Manisha Rao
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A wonderful， optimistic book that aligns with a lot of my mother's predictions about genetics。 A tad bit too technical and a few things seemed repetitive but the story-telling/anecdotal format makes it a good read nonetheless。Bookmarked all the things that'll help slow down ageing :D A wonderful， optimistic book that aligns with a lot of my mother's predictions about genetics。 A tad bit too technical and a few things seemed repetitive but the story-telling/anecdotal format makes it a good read nonetheless。Bookmarked all the things that'll help slow down ageing :D 。。。more
Alex Artamonova
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A whole lot to process， but concrete evidence as to why we might soon be living past 120 and a good argument for keeping our bodies healthy until then！
William Adams
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Advances in understanding the human genome have led to some remarkable findings that could change medicine。 David Sinclair is a biomedical researcher who concludes that the human lifespan could be extended by at least 40 years relatively soon。 Aging is a disease， he says， not inevitable。 Like any disease， aging can be cured。 Sinclair describes recent and ongoing scientific research in genomics， nutrition， and pharmacology that might extend the human lifespan。 Some of the applications have been s Advances in understanding the human genome have led to some remarkable findings that could change medicine。 David Sinclair is a biomedical researcher who concludes that the human lifespan could be extended by at least 40 years relatively soon。 Aging is a disease， he says， not inevitable。 Like any disease， aging can be cured。 Sinclair describes recent and ongoing scientific research in genomics， nutrition， and pharmacology that might extend the human lifespan。 Some of the applications have been shown to significantly extend the lifespan of mice， fruit flies， and other laboratory animals。 In humans， not so much。 Doing hard， scientific research on the human lifespan is not easy。 You can’t knock out a gene or two to see if the person dies。 Sinclair is exuberantly optimistic about extending the human lifespan by applying extrapolations of suggestive laboratory findings。 While the book describes many important scientific outcomes in detail， speculation and personal anecdotes run way ahead of the facts。 Built into the book’s thesis are two critical assumptions hardly questioned。 One is that everyone wants a fountain of youth。 Who wouldn’t like to live 40 years longer – healthy， active， self-aware years， Sinclair says。 The presumptive answer is that everyone wants that。 But it is a question that deserves serious discussion。 Does a drug addict want 40 more years？ Does a prisoner with a life sentence？ What about someone deep in debt？ Does a hungry refugee in a war-torn relocation camp want 40 more years？ Could you afford your ever-increasing insurance premiums for 40 additional years？ Will the cities have enough food， housing， water， and medicine for a population that doesn’t die “on time？” Will the planet support that kind of increase in population？ Will younger people find jobs and advance their careers when the "elders" don’t die （don't even age）？ The second unquestioned assumption is that human life is best measured by counting Earth’s orbits around the sun。 No consideration is given to the arc of developmental psychology。 When I recall my self-awareness at age 25， I cringe。 If I stopped aging， would I stay 25 ？ Would I continue to develop psychologically for a hundred more years， even working at a meaningless job in a 25-year-old body surging with hormones？ It's imponderable。 A good meal and a hot bath sound more attractive than being dead， for sure， but there’s more to life than biology。 Most troubling， the term aging is not well defined in the book and does not appear in the glossary。 In the index， its main entry refers to a page describing “markers” of aging。 “Marker” is not defined， but we might take it to be similar to a symptom， since the author believes that aging is a disease。 “Disease” is not defined and does not appear in the glossary or the index。 Other undefined terms include “life” and “death。” The closest the author comes to a definition of his subject matter is on page 20， where he boldly declares that “Aging， quite simply， is a loss of information。” That sounds pretty clear until you learn that “information” is defined as entropy reduction， following Claude Shannon’s famous 1948 paper。 But that definition is tautological: The better you can determine the value of a probabilistic variable， the more information you have about it。 The book is an exercise in superficial futurism more than a serious essay about the meaning and possibilities of the human lifespan。 It is naïve about economics， politics， demographics， sociology， psychology， agriculture， urban planning， history， and much else。 As a science popularization， it does not succeed， though it is worth a skim for its thought-provoking moments。Sinclair， David A。， with Matthew D。 LaPlante （2019）。 Lifespan: Why we Age and Why we Don’t Have To。 London: Thorsons， 404 pp。 。。。more
Lucas Wilson
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The first half of this book is inspirational and incredibly clear， the second half is quite wishy-washy， and frankly a bit disappointing， but overall the book is definitely worth a read and it is definitely one of the better pop-sci books I've read The first half of this book is inspirational and incredibly clear， the second half is quite wishy-washy， and frankly a bit disappointing， but overall the book is definitely worth a read and it is definitely one of the better pop-sci books I've read 。。。more
Katney
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Listened to this one。 Interesting reading on the thoughts behind aging: why it happens， how to reverse it， how to classify it， the concept of living well after your first century of life。 Ideas for supplements （resveratrol， nmn， metformin for example）。 What happens to quality of life if humans start living so long: the state of the earth and its resources to sustain us， how humans behave towards each other， etc。
Greg Mork
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This kind of book is right up my alley （that is， the Why We Sleep by Matthew Walker and Being Mortal by Atul Gawande alley）。 Sinclair can get pretty technical for an average fella like me， but most of the content is accessible and it's an easy read with plenty of anecdotes and humor。 Brb， gonna go fast now。 This kind of book is right up my alley （that is， the Why We Sleep by Matthew Walker and Being Mortal by Atul Gawande alley）。 Sinclair can get pretty technical for an average fella like me， but most of the content is accessible and it's an easy read with plenty of anecdotes and humor。 Brb， gonna go fast now。 。。。more
Alex Smith
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David Sinclair writes in an engaging and relevant manner on a topic that we all experience， aging。 His approach to treating aging like a disease rather than an inevitable part of life is very though provoking and inspirational。 His optimism on what the future of humanity holds is a breath of fresh air in what is otherwise a wildly negatively based world of scientific doom and gloom。 Some practical behaviours that most of us can adopt makes this book not only entertaining but also very useful as David Sinclair writes in an engaging and relevant manner on a topic that we all experience， aging。 His approach to treating aging like a disease rather than an inevitable part of life is very though provoking and inspirational。 His optimism on what the future of humanity holds is a breath of fresh air in what is otherwise a wildly negatively based world of scientific doom and gloom。 Some practical behaviours that most of us can adopt makes this book not only entertaining but also very useful as a guide for lifestyle changes to slow our biological clock。 Will I begin to see less greys on my beard。。。 I hope so。 。。。more
Vinicius
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Great book， don't agree with a lot of it， but a lot of important questions were raised， concerning the coming years and the research on longevity。 Great book， don't agree with a lot of it， but a lot of important questions were raised， concerning the coming years and the research on longevity。 。。。more
Roy Foley
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Unreal book 👌
Jurate
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Pati autoriaus nagrinėjama sritis labai įdomi - juk turbūt daugelis iš mūsų norėtume ne tik tiesiog gyventi ilgai， bet iki pat pabaigos gyventi pilnavertį gyvenimą ir nebūti našta kitiems。 Būtent ta kryptimi eina jo tyrimai， kai ieškoma ne tik būdų prailginti gyvenimo trukmę， bet padaryti tai taip， kad gyventi ilgiau išties būtų verta。 Nes pratęsti gyvenimą dirbtinai tik tam， kad ilgiau kankintum ir save ir artimuosius， kaip ir D。 Sinclair rašo， joks ne laimėjimas， o tiesiog nuodėmė。 Tik jei kal Pati autoriaus nagrinėjama sritis labai įdomi - juk turbūt daugelis iš mūsų norėtume ne tik tiesiog gyventi ilgai， bet iki pat pabaigos gyventi pilnavertį gyvenimą ir nebūti našta kitiems。 Būtent ta kryptimi eina jo tyrimai， kai ieškoma ne tik būdų prailginti gyvenimo trukmę， bet padaryti tai taip， kad gyventi ilgiau išties būtų verta。 Nes pratęsti gyvenimą dirbtinai tik tam， kad ilgiau kankintum ir save ir artimuosius， kaip ir D。 Sinclair rašo， joks ne laimėjimas， o tiesiog nuodėmė。 Tik jei kalbant apie pačią knygą， kas man kiek kliuvo， kad lyg neapsispręsta， kam ji rašoma - kai kurie skyriai lyg visiškai populistiniai， kiti - tokie， kur， turėdama tik mokyklinius biologijos pagrindus， turėjau sau pripažinti， kad skaitau， bet iš tiesų nesuprantu。 Nors， tiesą sakant， paskutinė dalis lyg aiškiausiai parodė tos knygos tikslą - įrodyti， kad jo sritiems tyrimams verta skirti finansavimą。 Nesakau， kad nereikia - tik mane kiek suerzino toks gana tiesmukas lobizmas。 Bet šiaip， kad ir suprantant tik paviršių， tikrai buvo įdomu sužinoti， kiek jau bent teoriniame lygmenyje nuveikta ieškant būdų sustabdyti senėjimą ir kur mes， kaip visuomenė， galime keliauti toliau。 Jei， kaip autorius žada， greitai nieko nebestebins 120 metų gyvenimo trukmė， galėsiu kokį dešimtmetį pasilikti ir giliau toms temoms panagrinėti ir išties suprasti :） 。。。more
David
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What if we could lead healthy and productive lives well past the age of 100？ This type of question was considered silly and not worthy of considering just a little while ago。 Dr。 Sinclair has been using the latest in biotechnology， genetics and pharmacology to attack this very question for decades now。 His basic assertion is that we age not because of a failure in our DNA but due to the weakening of the epigenetic components in cells that keep our DNA doing what it is supposed to do。 Dr。 Sinclai What if we could lead healthy and productive lives well past the age of 100？ This type of question was considered silly and not worthy of considering just a little while ago。 Dr。 Sinclair has been using the latest in biotechnology， genetics and pharmacology to attack this very question for decades now。 His basic assertion is that we age not because of a failure in our DNA but due to the weakening of the epigenetic components in cells that keep our DNA doing what it is supposed to do。 Dr。 Sinclair is not a flake。 He is the co-director of the Paul F。 Glenn Center for the Biology of Aging at Harvard Medical School。 He is also an advisor to the TB12 Scientific Advisory Board， the one helping Tom Brady do what he does。 He touches on the darker side of longer lifetimes on society， but addresses these concerns fairly well。 This book presents a largely optimistic perspective on a number of actions that people can do to give them better odds of living longer and healthier lives。 Well worth reading！ 。。。more
Robert Banovský
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Not having read other books about modern theories of ageing， this was a breathtaking read for me。 Ideas like ageing is not inevitable， it is real to reach 150 years and more and such are really worth poring over
Annalisa
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Parts are technical and require understanding of scientific jargon but he does a good job of paraphrasing and using metaphors to help you understand the concepts。 The content is so eye opening！
Damian
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Mildy interesting for the most part。Key take aways:* science will provide us with incredible longevity therapies* starting now you can fast， exercise， eat properly and you'll already get many benefits Mildy interesting for the most part。Key take aways:* science will provide us with incredible longevity therapies* starting now you can fast， exercise， eat properly and you'll already get many benefits 。。。more
Ernie
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Exicting survey of research & progress on ageing。 Easy to read and interesting content。
Vasco
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